S13-3CURRENT VIEWS ON PENTOXIFYLLINE ISSUE FOR ACUTE ALCOHOLIC STEATOHEPATITIS
نویسندگان
چکیده
منابع مشابه
Effects of Pentoxifylline on Non-Alcoholic Steatohepatitis: A Randomized, Double-Blind, Placebo-Controlled Trial in Iran
BACKGROUND Non-alcoholic steatohepatitis (NASH) is a progressive form of nonalcoholic fatty liver disease. Several studies suggest that pentoxifylline (PTX) can improve the disease outcome. OBJECTIVES We aimed to compare the effect of pentoxifylline with placebo on liver aminotransferases and cytokines, including interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-α), and interleukin 8 (IL...
متن کاملPentoxifylline for the treatment of non-alcoholic steatohepatitis: a randomized controlled trial.
INTRODUCTION The burden of non-alcoholic steatohepatitis (NASH) is growing and current pharmacologic treatments are limited by side effects and inconsistent efficacy. Pilot studies suggest that pentoxifylline (PTX) can reduce liver injury in patients with NASH. OBJECTIVE We sought to determine the tolerability of PTX and its effect on aminotransferases and liver histology in patients with NAS...
متن کاملeffects of pentoxifylline on non-alcoholic steatohepatitis: a randomized, double-blind, placebo-controlled trial in iran
conclusions decreases in the serum levels of liver aminotransferases and cytokines, in both groups, are related to low-calorie diets and exercise, rather than ptx. results the serum levels of liver aminotransferases were significantly reduced at 3 months and at 6 months, compared with baseline, in both groups. the serum levels of il-6 were significantly decreased, in both groups, only at 6 mont...
متن کاملPrednisolone or pentoxifylline for alcoholic hepatitis.
BACKGROUND Alcoholic hepatitis is a clinical syndrome characterized by jaundice and liver impairment that occurs in patients with a history of heavy and prolonged alcohol use. The short-term mortality among patients with severe disease exceeds 30%. Prednisolone and pentoxifylline are both recommended for the treatment of severe alcoholic hepatitis, but uncertainty about their benefit persists. ...
متن کاملUpdate on the management of alcoholic steatohepatitis.
Among heavy drinkers with liver disease, the development of severe alcoholic hepatitis (AH) is a serious complication. Prognosis is grave and associated with a high mortality due to liver failure, hepatorenal syndrome or intractable sepsis. Clinically, AH presents as a syndrome of progressive inflammatory liver injury in patients with recent or ongoing heavy alcohol consumption. Although approx...
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ژورنال
عنوان ژورنال: Alcohol and Alcoholism
سال: 2017
ISSN: 0735-0414,1464-3502
DOI: 10.1093/alcalc/agx075.49